DISEASES

Disease-gene associations mined from literature

Literature on GUK1

GUK1 [ENSP00000355689]

Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) . Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors . In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273,; Belongs to the guanylate kinase family.

Synonyms:  GUK1,  GUK1p,  hGUK1,  B1ANG9,  B1ANH0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM