DISEASES

Disease-gene associations mined from literature

Literature on FRMD4B

FRMD4B [ENSP00000381549]

FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization.

Synonyms:  FRMD4B,  FRMD4Bp,  hFRMD4B,  C9J6Q2,  C9J7M5 ...

Linkouts:  STRING  Pharos  UniProt