DISEASES

Disease-gene associations mined from literature

Literature on KDM7A

KDM7A [ENSP00000380692]

Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. ; Belongs to the JHDM1 histone demethylase family. JHDM1D subfamily.

Synonyms:  KDM7A,  KDM7Ap,  hKDM7A,  H9KVD6,  Q6ZMT4 ...

Linkouts:  STRING  Pharos  UniProt