Literature on RAPGEF1
RAPGEF1 [ENSP00000361264]
Rap guanine nucleotide exchange factor 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
Synonyms: RAPGEF1, RAPGEF1p, hRAPGEF1, H0Y4V2, H0Y6R4 ...