DISEASES

Disease-gene associations mined from literature

Literature on FMO3

FMO3 [ENSP00000356729]

Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds . Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite . TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation . ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:9224773,; Belongs to the FMO family.

Synonyms:  FMO3,  FMO3p,  hFMO3,  A0A024R8Z4,  P31513 ...

Linkouts:  STRING  Pharos  UniProt  OMIM