DISEASES

Disease-gene associations mined from literature

Literature on RIOK3

RIOK3 [ENSP00000341874]

Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 . Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling . Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway . May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA . ; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.

Synonyms:  RIOK3,  RIOK3p,  hRIOK3,  B0YJ89,  B4E1Q4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM