Literature on PIDD1
PIDD1 [ENSP00000337797]
P53-induced death domain-containing protein 1; Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis (PubMed:10973264, PubMed:15073321, PubMed:16360037, PubMed:17159900). Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis . Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (PubMed:16360037, PubMed:17159900). ECO:0000269|PubMed:15073321, ECO:0000269|PubMed:16360037,
Synonyms: PIDD1, PIDD1p, hPIDD1, E9PPT6, H0YE55 ...