DISEASES

Disease-gene associations mined from literature

Literature on SGPP2

SGPP2 [ENSP00000315137]

Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro . Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling . Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (By similarity). ECO:0000250|UniProtKB:Q9BX95, ECO:0000269|PubMed:12411432,

Synonyms:  SGPP2,  SGPP2p,  hSGPP2,  Q8IWX5,  Q8IWX5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM