DISEASES

Disease-gene associations mined from literature

Literature on NFKBIB

NFKBIB [ENSP00000312988]

NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Synonyms:  NFKBIB,  G5E9C2,  H0YFH0,  I3L1A4,  I3L4X3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM