DISEASES

Disease-gene associations mined from literature

Literature on CASP2

CASP2 [ENSP00000312664]

Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress .

Synonyms:  CASP2,  CASP2p,  hCASP2,  A0A087WYM1,  A0A0S2Z3H1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM