DISEASES

Disease-gene associations mined from literature

Literature on PPARGC1B

PPARGC1B [ENSP00000312649]

Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non- oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003,

Synonyms:  PPARGC1B,  H0Y713,  Q86YN6,  H0Y713p,  hH0Y713 ...

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