DISEASES

Disease-gene associations mined from literature

Literature on H2AZ1

H2AZ1 [ENSP00000296417]

Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

Synonyms:  H2AZ1,  H2AZ1p,  hH2AZ1,  A0A494C189,  H2AFZ ...

Linkouts:  STRING  Pharos  UniProt  OMIM