Literature on MACROD1
MACROD1 [ENSP00000255681]
ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen . May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation . Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction . Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells . Enhances ESR1-mediated transcription activity . ECO:0000269|PubMed:17914104, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19403568, ECO:0000269|PubMed:21257746,
Synonyms: MACROD1, MACROD1p, hMACROD1, Q9BQ69, Q9BQ69p ...