DISEASES

Disease-gene associations mined from literature

Literature on NPLOC4

NPLOC4 [ENSP00000331487]

Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I .

Synonyms:  NPLOC4,  NPLOC4p,  hNPLOC4,  A0A024R8R4,  A0A0D9SFI9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM