DISEASES

Disease-gene associations mined from literature

Literature on USP1

USP1 [ENSP00000343526]

Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 . Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA . Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity .

Synonyms:  USP1,  USP1p,  hUSP1,  C9JC88,  C9JWX4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM