DISEASES

Disease-gene associations mined from literature

Literature on PRDX1

PRDX1 [ENSP00000262746]

Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) . Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity).

Synonyms:  PRDX1,  PRDX1p,  hPRDX1,  A0A0A0MRQ5,  A0A0A0MSI0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM