DISEASES

Disease-gene associations mined from literature

Literature on ZFPM2

ZFPM2 [ENSP00000384179]

Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity); Belongs to the FOG (Friend of GATA) family.

Synonyms:  ZFPM2,  ZFPM2p,  hZFPM2,  E5RJX0,  E7ET52 ...

Linkouts:  STRING  Pharos  UniProt  OMIM