DISEASES

Disease-gene associations mined from literature

Literature on EPG5

EPG5 [ENSP00000282041]

Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located .

Synonyms:  EPG5,  EPG5p,  hEPG5,  K7EM87,  K7ENK5 ...

Linkouts:  STRING  Pharos  UniProt