DISEASES

Disease-gene associations mined from literature

Literature on PM20D1

PM20D1 [ENSP00000356104]

N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration.

Synonyms:  PM20D1,  PM20D1p,  hPM20D1,  Q6GTS8,  Q6GTS8p ...

Linkouts:  STRING  Pharos  UniProt