DISEASES

Disease-gene associations mined from literature

Literature on PLAAT2

PLAAT2 [ENSP00000255695]

Phospholipase A and acyltransferase 2; Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22825852, PubMed:22605381, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22825852, PubMed:22605381). For most substrates, PLA1 activity is much higher than PLA2 activity . Shows O- acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which serves as precursor for N- acylethanolamines (NAEs) (PubMed:19615464, PubMed:22825852, PubMed:22605381). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor . Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity . ECO:0000269|PubMed:22605381, ECO:0000269|PubMed:22825852,

Synonyms:  PLAAT2,  PLAAT2p,  hPLAAT2,  Q9NWW9,  Q9NWW9p ...

Linkouts:  STRING  Pharos  UniProt  OMIM