DISEASES

Disease-gene associations mined from literature

Literature on USP51

USP51 [ENSP00000423333]

Ubiquitin carboxyl-terminal hydrolase 51; Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys- 16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs) . USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin .

Synonyms:  USP51,  USP51p,  hUSP51,  A0A1B0GVA6,  Q70EK9 ...

Linkouts:  STRING  Pharos  UniProt