DISEASES

Disease-gene associations mined from literature

Literature associating CTDP1 and Charcot-Marie-Tooth disease dominant intermediate A

CTDP1 [ENSP00000484525]

RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation.

Synonyms:  CTDP1,  CTDP1p,  hCTDP1,  A0A0A0MR03,  K7EJD2 ...

Linkouts:  STRING  Pharos  UniProt