DISEASES

Disease-gene associations mined from literature

Literature associating H2AB1 and anus benign neoplasm

H2AB1 [ENSP00000484261]

Histone H2A-Bbd type 1; Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase . They associate with spliceosome components and are required for mRNA splicing . ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134,

Synonyms:  H2AB1,  H2AB1p,  hH2AB1,  H2AFB1,  P0C5Y9 ...

Linkouts:  STRING  Pharos  UniProt