DISEASES

Disease-gene associations mined from literature

Literature associating TSPAN33 and cerebral artery occlusion

TSPAN33 [ENSP00000483872]

Tetraspanin-33; Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26686862, PubMed:30463011). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity . Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 .

Synonyms:  TSPAN33,  TSPAN33p,  hTSPAN33,  Q86UF1,  Q86UF1p ...

Linkouts:  STRING  Pharos  UniProt