DISEASES

Disease-gene associations mined from literature

Literature associating IFI27 and papilloma

IFI27 [ENSP00000483430]

Interferon alpha-inducible protein 27, mitochondrial; Probable adapter protein involved in different biological processes . Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 . Also functions in TNFSF10-induced apoptosis . May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors . May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the virus by recruiting both the hepatitis C virus non-structural protein 5A/NS5A and the ubiquitination machinery via SKP2, promoting the ubiquitin- mediated proteasomal degradation of NS5A (PubMed:27194766, PubMed:27777077). ECO:0000269|PubMed:18330707, ECO:0000269|PubMed:22427340, ECO:0000269|PubMed:24970806, ECO:0000269|PubMed:27194766,; Belongs to the IFI6/IFI27 family.

Synonyms:  IFI27,  IFI27p,  hIFI27,  A0A087WUJ8,  A0A087WV79 ...

Linkouts:  STRING  Pharos  UniProt