DISEASES

Disease-gene associations mined from literature

Literature associating PRLR and breast disease

PRLR [ENSP00000482954]

Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Synonyms:  PRLR,  D6R9E1,  D6R9P5,  D6R9V7,  D6RAN9 ...

Linkouts:  STRING  Pharos  UniProt