DISEASES

Disease-gene associations mined from literature

Literature associating TYW1B and Sorsby's fundus dystrophy

TYW1B [ENSP00000482502]

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity).

Synonyms:  TYW1B,  TYW1Bp,  hTYW1B,  A0A087WWV6,  A0A087X1V1 ...

Linkouts:  STRING  Pharos  UniProt