DISEASES

Disease-gene associations mined from literature

Literature associating CCL4 and latex allergy

CCL4 [ENSP00000482259]

C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T- cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1- beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. ; Belongs to the intercrine beta (chemokine CC) family.

Synonyms:  CCL4,  CCL4p,  hCCL4,  P13236,  Q7M4M2 ...

Linkouts:  STRING  Pharos  UniProt