Literature associating PRAG1 and retinitis pigmentosa 18
PRAG1 [ENSP00000481109]
Inactive tyrosine-protein kinase PRAG1; Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling (By similarity).
Synonyms: PRAG1, PRAG1p, hPRAG1, Q86YV5, Q86YV5p ...