Literature associating TADA2A and chromosome 17q12 deletion syndrome
TADA2A [ENSP00000481091]
Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity . May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage .
Synonyms: TADA2A, TADA2Ap, hTADA2A, A0A024R0Y4, A0A087WTV5 ...