DISEASES

Disease-gene associations mined from literature

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Literature associating IQSEC1 and aphasia

IQSEC1 [ENSP00000480301]

IQ motif and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF1 and ARF6 . Guanine nucleotide exchange factor activity is enhanced by lipid binding . Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.

Synonyms:  IQSEC1,  IQSEC1p,  hIQSEC1,  A0A087WWK8,  A0A0C4DGT3 ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.