DISEASES

Disease-gene associations mined from literature

Literature associating LRRC8E and steroid-induced glaucoma

LRRC8E [ENSP00000479953]

Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress . Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition .

Synonyms:  LRRC8E,  LRRC8Ep,  hLRRC8E,  M0QZ48,  M0R2D8 ...

Linkouts:  STRING  Pharos  UniProt