Literature associating ACSF3 and combined malonic and methylmalonic acidemia
ACSF3 [ENSP00000479130]
Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester (PubMed:21846720, PubMed:21841779). May have some preference toward very-long-chain substrates ; Belongs to the ATP-dependent AMP-binding enzyme family.
Synonyms: ACSF3, ACSF3p, hACSF3, A0A3B3ISK9, F5GX20 ...