DISEASES

Disease-gene associations mined from literature

Literature associating FRK and co-trimoxazole allergy

FRK [ENSP00000476145]

Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Synonyms:  FRK,  P42685,  P42685p,  hP42685,  2444 ...

Linkouts:  STRING  Pharos  UniProt