DISEASES

Disease-gene associations mined from literature

Literature associating H2BC11 and congenital vertical talus

H2BC11 [ENSP00000476136]

Histone H2B type 1-J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Synonyms:  H2BC11,  H2BC11p,  hH2BC11,  A0A024RCJ2,  HIST1H2BJ ...

Linkouts:  STRING  Pharos  UniProt