Literature associating APLNR and pulmonary venoocclusive disease
APLNR [ENSP00000475344]
Apelin receptor; Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity . Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure . ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199,
Synonyms: APLNR, P35414, P35414p, hP35414, 2LOT ...