DISEASES

Disease-gene associations mined from literature

Literature associating TXNIP and exocervical carcinoma

TXNIP [ENSP00000462521]

Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147,

Synonyms:  TXNIP,  A0A024R4B7,  Q9H3M7,  Q9H3M7p,  hQ9H3M7 ...

Linkouts:  STRING  Pharos  UniProt