DISEASES

Disease-gene associations mined from literature

Literature associating ZP2 and megalencephalic leukoencephalopathy with subcortical cysts

ZP2 [ENSP00000460971]

Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy . The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor .

Synonyms:  ZP2,  ZP2p,  hZP2,  Q05996,  Q05996p ...

Linkouts:  STRING  Pharos  UniProt