DISEASES

Disease-gene associations mined from literature

Literature associating WWOX and squamous cell carcinoma

WWOX [ENSP00000457230]

WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. ECO:0000269|PubMed:11719429, ECO:0000269|PubMed:15070730, ECO:0000269|PubMed:15548692, ECO:0000269|PubMed:16061658, ECO:0000269|PubMed:16219768, ECO:0000269|PubMed:19366691,

Synonyms:  WWOX,  A0A087WZG5,  A0A411HBC7,  F5H3R5,  H3BMD1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM