Literature associating DTX3 and arteriovenous malformations of the brain
DTX3 [ENSP00000448696]
Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context (By similarity). Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Synonyms: DTX3, DTX3p, hDTX3, A0A024RB96, A0A0C4DGI8 ...