DISEASES

Disease-gene associations mined from literature

Literature associating RITA1 and anus cancer

RITA1 [ENSP00000448680]

RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Synonyms:  RITA1,  RITA1p,  hRITA1,  A0A024RBL1,  A0A087X1G3 ...

Linkouts:  STRING  Pharos  UniProt