DISEASES

Disease-gene associations mined from literature

Literature associating FRY and dextro-looped transposition of the great arteries

FRY [ENSP00000445043]

Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. ; Belongs to the furry protein family.

Synonyms:  FRY,  A0A0C4DFX2,  A0A286YFA9,  A0A2R8Y5V8,  A0A2R8Y7Y8 ...

Linkouts:  STRING  Pharos  UniProt