DISEASES

Disease-gene associations mined from literature

Literature associating POLR1B and acute salpingitis

POLR1B [ENSP00000444136]

DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

Synonyms:  POLR1B,  POLR1Bp,  hPOLR1B,  C9JJG2,  C9JS83 ...

Linkouts:  STRING  Pharos  UniProt