DISEASES

Disease-gene associations mined from literature

SearchDownloadsAbout

Literature associating TBC1D10C and Crouzon syndrome-acanthosis nigricans syndrome

TBC1D10C [ENSP00000443654]

Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras.

Synonyms:  TBC1D10C,  E9PSB7,  Q8IV04,  E9PSB7p,  hE9PSB7 ...

Linkouts:  STRING  Pharos  UniProt

The disease-gene associations are derived from automatic text mining of the biomedical literature, manually curated database annotations, cancer mutation data, and genome-wide association studies. The confidence of each association is signified by stars, where ★★★★★ is the highest confidence and ★☆☆☆☆ is the lowest.

Developed by Sune Frankild, Alexander Junge, Albert Pallejà, Dhouha Grissa, Kalliopi Tsafou, and Lars Juhl Jensen from the Novo Nordisk Foundation Center for Protein Research.