Literature associating ORC4 and Seckel syndrome
ORC4 [ENSP00000441953]
Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3; Belongs to the ORC4 family.
Synonyms: ORC4, ORC4p, hORC4, C9J2X8, C9JGH7 ...