DISEASES

Disease-gene associations mined from literature

Literature associating PHB2 and drug psychosis

PHB2 [ENSP00000441875]

Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity . ECO:0000269|PubMed:10359819, ECO:0000269|PubMed:20959514,

Synonyms:  PHB2,  PHB2p,  hPHB2,  F5GWA7,  F5GY37 ...

Linkouts:  STRING  Pharos  UniProt  OMIM