DISEASES

Disease-gene associations mined from literature

Literature associating PLEKHG5 and muscular atrophy

PLEKHG5 [ENSP00000439625]

Pleckstrin homology domain-containing family G member 5; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation . Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts .

Synonyms:  PLEKHG5,  PLEKHG5p,  hPLEKHG5,  O94827,  Q5SY18 ...

Linkouts:  STRING  Pharos  UniProt