DISEASES

Disease-gene associations mined from literature

Literature associating HTR2A and attention deficit hyperactivity disorder

HTR2A [ENSP00000437737]

5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin) . Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2- aminopropane (DOI) and lysergic acid diethylamide (LSD) . Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors . Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways . Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores . Affects neural activity, perception, cognition and mood . Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction. ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:21645528,

Synonyms:  HTR2A,  HTR2Ap,  hHTR2A,  A0A087WZJ9,  P28223 ...

Linkouts:  STRING  Pharos  UniProt