DISEASES

Disease-gene associations mined from literature

Literature associating CASP1 and Schnitzler syndrome

CASP1 [ENSP00000433138]

Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive . In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly . ECO:0000269|PubMed:1574116, ECO:0000269|PubMed:20197547,; Belongs to the peptidase C14A family.

Synonyms:  CASP1,  CASP1p,  hCASP1,  A0A1W2PRX7,  B4DVD8 ...

Linkouts:  STRING  Pharos  UniProt