DISEASES

Disease-gene associations mined from literature

Literature associating LPXN and lipid metabolism disorder

LPXN [ENSP00000431284]

Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling.

Synonyms:  LPXN,  B7Z5P7,  E9PNX9,  O60711,  B7Z5P7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM